Zika virus cell tropism in the developing human brain and inhibition by azithromycin
University of California, San Francisco · Broad Center · +3 more institutions
Abstract
The rapid spread of Zika virus (ZIKV) and its association with abnormal brain development constitute a global health emergency. Congenital ZIKV infection produces a range of mild to severe pathologies, including microcephaly. To understand the pathophysiology of ZIKV infection, we used models of the developing brain that faithfully recapitulate the tissue architecture in early to midgestation. We identify the brain cell populations that are most susceptible to ZIKV infection in primary human tissue, provide evidence for a mechanism of viral entry, and show that a commonly used antibiotic protects cultured brain cells by reducing viral proliferation. In the brain, ZIKV preferentially infected neural stem cells,…
Citation impact
- FWCI
- 54.60
- Percentile
- 100%
- References
- 34
Authors
15- HRHanna RetallackCorresponding
University of California, San Francisco
- EDElizabeth Di Lullo
University of California, San Francisco, Broad Center
- CACarolina Arias
University of California, Santa Barbara, University of California, San Francisco
- KAKristeene A. Knopp
University of California, San Francisco
- MTMatthew T. Laurie
University of California, San Francisco
Topics & keywords
- Microcephaly
- Zika virus
- Biology
- Virology
- Tropism
- Tissue tropism
- Neural stem cell
- Flavivirus
- Good health and well-being