articleCell ReportsDec 1, 2016GOLD OA

Immunometabolic Pathways in BCG-Induced Trained Immunity

RJRob J.W. ArtsACAgostinho CarvalhoCLClaudia La RoccaCPCarla PalmaFRFernando Rodrigues

Radboud University Nijmegen · Radboud University Medical Center · +6 more institutions

PubMed
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Abstract

The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term metabolic changes and chromatin remodeling through histone modifications in innate immune cells such as monocytes, a process termed trained immunity. Here, we show that BCG induction of trained immunity in monocytes is accompanied by a strong increase in glycolysis and, to a lesser extent, glutamine metabolism, both in an in-vitro model and after vaccination of mice and humans. Pharmacological and genetic modulation of rate-limiting glycolysis enzymes inhibits trained immunity, changes that are reflected by the effects on the histone marks (H3K4me3 and H3K9me3)…

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652
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Authors

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Topics & keywords

Topics
Keywords
  • Immunity
  • Biology
  • Histone
  • Immune system
  • Glycolysis
  • Innate immune system
  • Immunology
  • Metabolic pathway
UN Sustainable Development Goals
  • Good health and well-being
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