The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation

The immune system has the difficult challenge of discerning and defending against a diversity of microbial pathogens, while simultaneously avoiding self-reactivity. T lymphocytes function as effectors and regulators of the immune system. While central tolerance mechanism results in deletion of the majority of self-reactive T lymphocytes during thymic selection, a fraction of self reactive lymphocytes escapes to the periphery and retains the potential to inflict destructive autoimmune pathology. The immune system evolved various mechanisms to restrain such auto-reactive T cells and maintain peripheral tolerance, including T cell anergy, deletion, and suppression by regulatory T cells (TRegs). These effects are…

• UD
  U.S. Department of Defense

  Award: PC140571
• FF
  Foundation for the National Institutes of Health

  Award: CA183605, CA183605S1, AI098129-01