Multicopper Laccase Mimicking Nanozymes with Nucleotides as Ligands

Using nanomaterials to achieve functional enzyme mimics (nanozymes) is attractive for both applied and fundamental research. Laccases are multicopper oxidases highly important for biotechnology and environmental remediation. In this work, we report an exceptionally simple yet functional laccase mimic based on guanosine monophosphate (GMP) coordinated copper. It forms an amorphous metal–organic framework (MOF) material. The ratio of copper and GMP is 3:4 as determined by isothermal titration calorimetry. It has excellent laccase-like activity and converts a diverse range of phenol containing substrates such as hydroquinone, naphthol, catechol and epinephrine. Comparative work shows that the activity is…

• MO
  Ministry of Education of the People's Republic of China

  Award: YS1407
• SA
  State Administration of Foreign Experts Affairs
• CS
  China Scholarship Council
• NS
  Natural Science Foundation of Beijing Municipality

  Award: 2162030
• NS
  Natural Sciences and Engineering Research Council of Canada