reviewJournal of DiabetesJan 3, 2017BRONZE OA

Macro‐ and microvascular endothelial dysfunction in diabetes

YSYi ShiPMPaul M. Vanhoutte

Sun Yat-sen University · Fudan University · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Endothelial cells, as well as their major products nitric oxide (NO) and prostacyclin, play a key role in the regulation of vascular homeostasis. Diabetes mellitus is an important risk factor for cardiovascular disease. Diabetes-induced endothelial dysfunction is a critical and initiating factor in the genesis of diabetic vascular complications. The present review focuses on both large blood vessels and the microvasculature. The endothelial dysfunction in diabetic macrovascular complications is characterized by reduced NO bioavailability, poorly compensated for by increased production of prostacyclin and/or endothelium-dependent hyperpolarizations, and increased production or action of endothelium-derived…

Citation impact

546
total citations
FWCI
22.04
Percentile
100%
References
215
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Endothelial dysfunction
  • Medicine
  • Prostacyclin
  • Diabetes mellitus
  • Endothelium
  • Vasodilation
  • Nitric oxide
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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