Metalloporphyrin-Encapsulated Biodegradable Nanosystems for Highly Efficient Magnetic Resonance Imaging-Guided Sonodynamic Cancer Therapy
University of Shanghai for Science and Technology · Jiangsu University · +3 more institutions
Abstract
Traditional photodynamic therapy (PDT) suffers from the critical issues of low tissue-penetrating depth of light and potential phototoxicity, which are expected to be solved by developing new dynamic therapy-based therapeutic modalities such as sonodynamic therapy (SDT). In this work, we report on the design/fabrication of a high-performance multifunctional nanoparticulate sonosensitizer for efficient in vivo magnetic resonance imaging (MRI)-guided SDT against cancer. The developed approach takes the structural and compositional features of mesoporous organosilica-based nanosystems for the fabrication of sonosensitizers with intriguing theranostic performance. The well-defined mesoporosity facilitates the high…
Citation impact
- FWCI
- 29.22
- Percentile
- 100%
- References
- 51
Authors
8- PHPing HuangCorresponding
University of Shanghai for Science and Technology
- XQXiaoqin Qian
Jiangsu University, Affiliated Hospital of Jiangsu University
- YCYu Chen
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- LYLuodan Yu
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- HLHan Lin
Chinese Academy of Sciences, Shanghai Institute of Ceramics
Topics & keywords
- Sonodynamic therapy
- Chemistry
- Magnetic resonance imaging
- Cancer therapy
- Nuclear magnetic resonance
- Cancer
- Radiology
- Photodynamic therapy