Ageing and brain white matter structure in 3,513 UK Biobank participants

Cox, Simon R.; Ritchie, Stuart J.; Tucker–Drob, Elliot M.; Liewald, David C.; Hagenaars, Saskia P.; Davies, Gail; Wardlaw, Joanna M.; Galé, Catharine R.; Bastin, Mark E.; Deary, Ian J.

doi:10.1038/ncomms13629

articleNature CommunicationsDec 15, 2016GOLD OA

Ageing and brain white matter structure in 3,513 UK Biobank participants

SRSimon R. Cox SJStuart J. Ritchie EMElliot M. Tucker–Drob DCDavid C. Liewald SPSaskia P. Hagenaars

University of Edinburgh · The University of Texas at Austin · +3 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Quantifying the microstructural properties of the human brain's connections is necessary for understanding normal ageing and disease. Here we examine brain white matter magnetic resonance imaging (MRI) data in 3,513 generally healthy people aged 44.64-77.12 years from the UK Biobank. Using conventional water diffusion measures and newer, rarely studied indices from neurite orientation dispersion and density imaging, we document large age associations with white matter microstructure. Mean diffusivity is the most age-sensitive measure, with negative age associations strongest in the thalamic radiation and association fibres. White matter microstructure across brain tracts becomes increasingly correlated in…

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Topics & keywords

Topics

Keywords

White matter
Biobank
Human brain
Diffusion MRI
Ageing
Magnetic resonance imaging
Fractional anisotropy
Neuroimaging

UN Sustainable Development Goals

Clean water and sanitation

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