Virus taxonomy in the age of metagenomics

Simmonds, Peter; Adams, Mike; Benkő, Mária; Breitbart, Mya; Brister, J. Rodney; Carstens, Eric B.; Davison, Andrew J.; Delwart, Eric; Gorbalenya, Alexander E.; Harrach, Balázs; Hull, Roger; King, Andrew M. Q.; Koonin, Eugene V.; Krupovìč, Mart; Kuhn, Jens H.; Lefkowitz, Elliot J.; Nibert, Max L.; Orton, Richard; Roossinck, Marilyn J.; Sabanadzovic, Sead; Sullivan, Matthew B.; Suttle, Curtis A.; Tesh, Robert B.; Vlugt, R.A.A. van der; Varsani, Arvind; Zerbini, F. Murilo

doi:10.1038/nrmicro.2016.177

reviewNature Reviews MicrobiologyJan 3, 2017HYBRID OA

Virus taxonomy in the age of metagenomics

PSPeter Simmonds MAMike Adams MBMária Benkő MBMya Breitbart JRJ. Rodney Brister

University of Oxford · North Hertfordshire College · +35 more institutions

PubMed

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Abstract

The number and diversity of viral sequences that are identified in metagenomic data far exceeds that of experimentally characterized virus isolates. In a recent workshop, a panel of experts discussed the proposal that, with appropriate quality control, viruses that are known only from metagenomic data can, and should be, incorporated into the official classification scheme of the International Committee on Taxonomy of Viruses (ICTV). Although a taxonomy that is based on metagenomic sequence data alone represents a substantial departure from the traditional reliance on phenotypic properties, the development of a robust framework for sequence-based virus taxonomy is indispensable for the comprehensive…

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Topics

Keywords

Metagenomics
Human virome
Virus classification
Taxonomy (biology)
Biology
Computational biology
Genetics
Ecology

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