Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts

Over the past few years, substantial advances have been made in understanding the pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and prognostic parameters and novel therapeutic targets with demonstrable clinical impact have been identified. Several of these new markers, molecular targets, and therapeutic approaches have been validated and translated into clinical practice. At the same time, the classification of mastocytosis and related diagnostic criteria have been refined and updated by the consensus group and the World Health Organization (WHO). As a result, more specific therapies tailored toward prognostic subgroups of patients have been developed. Emerging treatment…

• DO
  Division of Intramural Research, National Institute of Allergy and Infectious Diseases
• AS
  Austrian Science Fund

  Awards: F4701, F4704-B20, F4701-B20
• NI
  National Institutes of Health
• NI
  National Institute of Allergy and Infectious Diseases
• ND
  NHLBI Division of Intramural Research