Comprehensive Insights into the Multi-Antioxidative Mechanisms of Melanin Nanoparticles and Their Application To Protect Brain from Injury in Ischemic Stroke
Brigham and Women's Hospital · Harvard University · +2 more institutions
Abstract
Nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for treating a myriad of important diseases through scavenging excessive reactive oxygen and nitrogen species (RONS), a mechanism critical in disease development and progression. However, similar to antioxidative enzymes, currently studied nanoantioxidants have demonstrated scavenging activity to specific RONS, and sufficient antioxidative effects against multiple RONS generated in diseases remain elusive. Here we propose to develop bioinspired melanin nanoparticles (MeNPs) for more potent and safer antioxidative therapy. While melanin is known to function as a potential radical scavenger, its antioxidative mechanisms are far from…
Citation impact
- FWCI
- 13.20
- Percentile
- 100%
- References
- 60
Authors
7- YLYanlan LiuCorresponding
Brigham and Women's Hospital, Harvard University, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- KAKelong Ai
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- XJXiaoyuan Ji
Brigham and Women's Hospital, Harvard University
- DADiana Askhatova
Brigham and Women's Hospital, Harvard University
- RDRose Du
Brigham and Women's Hospital, Harvard University
Topics & keywords
- Chemistry
- Reactive oxygen species
- Inflammation
- Pharmacology
- In vivo
- Stroke (engine)
- Reactive nitrogen species
- Biochemistry
Funding
- NNNational Natural Science Foundation of ChinaAwards: 21605137, 21635007
- MOMinistry of Science and Technology of the People's Republic of ChinaAward: 2016YFA0203200
- YIYouth Innovation Promotion Association of the Chinese Academy of SciencesAward: 2014201
- NCNational Cancer InstituteAwards: R00 CA160350, CA200900