reviewNew England Journal of MedicineSep 24, 2008GREEN OA

Lung Cancer

RSRoy S. HerbstJVJohn V. HeymachSMScott M. Lippman

The University of Texas MD Anderson Cancer Center

PubMed
Indexed incrossrefpubmed

Abstract

The Molecular Origins of Cancer series continues with this review of molecular and genetic mechanisms of lung cancer. The authors review genetic susceptibility to lung cancer and four genes of importance in the evolution of the disease: EGFR, KRAS, the PI3K–Akt–mTOR complex, and TITF1. They also discuss gene profiling and protein profiling, with emphasis on the clinical value of these methods.

Citation impact

2,384
total citations
FWCI
72.78
Percentile
100%
References
136
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • KRAS
  • Medicine
  • Lung cancer
  • PI3K/AKT/mTOR pathway
  • Disease
  • Gene
  • Bioinformatics
  • Cancer
UN Sustainable Development Goals
  • Good health and well-being
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Funding