Pharmacokinetic aspects of retinal drug delivery

Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness. Currently, intravitreal injections are the method of choice to administer drugs to the retina, but this approach is applicable only in selected cases (e.g. anti-VEGF antibodies and soluble receptors). There are two basic approaches that can be adopted to improve retinal drug delivery: prolonged and/or retina targeted delivery of intravitreal drugs and use of other routes of drug administration, such as periocular, suprachoroidal, sub-retinal, systemic, or topical. Properties of the administration route, drug and delivery system…

• IY
  Itä-Suomen Yliopisto
• AO
  Academy of Finland

  Awards: 263573, 272597, 283721, 268868, 263615
• T
  Tekes

  Award: 637/31/2015 TEKES
• SJ
  Sigrid Juséliuksen Säätiö

  Award: 64578
• SF
  Seventh Framework Programme