Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study
University of Cambridge · Cancer Research UK Cambridge Center · +3 more institutions
Abstract
BACKGROUND: Immune infiltration of breast tumours is associated with clinical outcome. However, past work has not accounted for the diversity of functionally distinct cell types that make up the immune response. The aim of this study was to determine whether differences in the cellular composition of the immune infiltrate in breast tumours influence survival and treatment response, and whether these effects differ by molecular subtype. METHODS AND FINDINGS: We applied an established computational approach (CIBERSORT) to bulk gene expression profiles of almost 11,000 tumours to infer the proportions of 22 subsets of immune cells. We investigated associations between each cell type and survival and response to…
Citation impact
- FWCI
- 15.72
- Percentile
- 100%
- References
- 54
Authors
5- HRH. Raza AliCorresponding
University of Cambridge, Cancer Research UK Cambridge Center, NIHR Cambridge Biomedical Research Centre
- LCLeon Chlon
Engineering and Physical Sciences Research Council, University of Cambridge, Cancer Research UK Cambridge Center, Cancer Imaging Centre
- PDPaul D.P. Pharoah
University of Cambridge, NIHR Cambridge Biomedical Research Centre
- FMFlorian Markowetz
Engineering and Physical Sciences Research Council, University of Cambridge, Cancer Research UK Cambridge Center, Cancer Imaging Centre
- CCCarlos Caldas
Engineering and Physical Sciences Research Council, University of Cambridge, Cancer Research UK Cambridge Center, NIHR Cambridge Biomedical Research Centre, Cancer Imaging Centre
Topics & keywords
- Immune system
- Breast cancer
- Hazard ratio
- CD8
- Biology
- Immunology
- Internal medicine
- Oncology
- No poverty