articleScienceJan 5, 2017BRONZE OA

Regeneration of fat cells from myofibroblasts during wound healing

MVMaksim V. PlikusCFChristian F. Guerrero‐JuarezMIMayumi ItoYRYun Rose LiPHPriya H. Dedhia

University of California, Irvine · University of Pennsylvania · +14 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Hair follicles: Secret to prevent scars? Although some animals easily regenerate limbs and heal broken flesh, mammals are generally not so gifted. Wounding can leave scars, which are characterized by a lack of hair follicles and cutaneous fat. Plikus et al. now show that hair follicles in both mice and humans can convert myofibroblasts, the predominant dermal cell in a wound, into adipocytes (see the Perspective by Chan and Longaker). The hair follicles activated the bone morphogenetic protein (BMP) signaling pathway and adipocyte transcription factors in the myofibroblast. Thus, it may be possible to reduce scar formation after wounding by adding BMP. Science , this issue p. 748 ; see also p. 693

Citation impact

572
total citations
FWCI
32.83
Percentile
100%
References
110
Citations per year

Authors

38

Topics & keywords

Topics
Keywords
  • Wound healing
  • Regeneration (biology)
  • Myofibroblast
  • Cell biology
  • Chemistry
  • Biology
  • Medicine
  • Pathology
No related works found for this paper.

Funding