FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol
Universidad de Santiago de Chile · Federico Santa María Technical University · +1 more institution
Abstract
The aim of this study was to prepare a novel targeting drug delivery system for 2-Methoxyestradiol (2ME) in order to improve the clinical application of this antitumor drug. It is based in nanoparticles (NPs) of titanium dioxide (TiO2) coated with polyethylene glycol (PEG) and loaded with 2ME. A complete IR and Raman characterization have been made to confirm the formation of TiO2–PEG–2ME composite. Vibrational modes have been assigned for TiO2, PEG, and 2ME and functionalized TiO2–PEG and TiO2–PEG–2ME. The observed variation in peak position of FTIR and Raman of each for these composites has been elucidated in terms of intermolecular interactions between PEG–2ME and TiO2, obtaining step-by-step the…
Citation impact
- FWCI
- 25.95
- Percentile
- 100%
- References
- 43
Authors
7- ALAndrea LeónCorresponding
Universidad de Santiago de Chile, Federico Santa María Technical University
- PRPatricia Reuquén
Universidad de Santiago de Chile
- CGCarolina Garín
Federico Santa María Technical University
- RSRodrigo Segura
University of Valparaíso
- PVP. Vargas
Universidad de Santiago de Chile, Federico Santa María Technical University
Topics & keywords
- Polyethylene glycol
- PEG ratio
- Nanocarriers
- Materials science
- Drug delivery
- Raman spectroscopy
- Fourier transform infrared spectroscopy
- Chemical engineering
- Good health and well-being