reviewGutJan 4, 2017HYBRID OA

Acute-on-chronic liver failure: an update

RHRubén HernáezESElsa SolàRMRichard MoreauPGPere Ginès

Michael E. DeBakey VA Medical Center · Baylor College of Medicine · +12 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Acute-on-chronic liver failure (ACLF) is a syndrome characterised by acute decompensation of chronic liver disease associated with organ failures and high short-term mortality. Alcohol and chronic viral hepatitis are the most common underlying liver diseases. Up to 40%-50% of the cases of ACLF have no identifiable trigger; in the remaining patients, sepsis, active alcoholism and relapse of chronic viral hepatitis are the most common reported precipitating factors. An excessive systemic inflammatory response seems to play a crucial role in the development of ACLF. Using a liver-adapted sequential organ assessment failure score, it is possible to triage and prognosticate the outcome of patients with ACLF. The…

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Authors

4

Topics & keywords

Topics
Keywords
  • Medicine
  • Decompensation
  • Intensive care medicine
  • Sepsis
  • Triage
  • Cirrhosis
  • Liver disease
  • Population
UN Sustainable Development Goals
  • Good health and well-being
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