Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

Askew, Katharine E.; Li, Kaizhen; Olmos‐Alonso, Adrián; García‐Moreno, Fernando; Liang, Yajie; Richardson, Philippa; Tipton, Tom; Chapman, Mark A.; Riecken, Kristoffer; Beccari, Sol; Sierra, Amanda; Molnár, Zoltán; Cragg, Mark S.; Garaschuk, Olga; Perry, V. Hugh; Gómez‐Nicola, Diego

doi:10.1016/j.celrep.2016.12.041

articleCell ReportsJan 1, 2017GOLD OA

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

KEKatharine E. Askew KLKaizhen Li AOAdrián Olmos‐Alonso FGFernando García‐Moreno YLYajie Liang

University of Southampton · Southampton General Hospital · +7 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis.…

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736

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FWCI: 35.55
Percentile: 100%
References: 49

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Authors

16

Topics & keywords

Topics

Keywords

Microglia
Neuroscience
Biology
Homeostasis
Population
Apoptosis
Cell biology
In vivo

UN Sustainable Development Goals

Good health and well-being

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