Integrated genomic characterization of oesophageal carcinoma

Park, Young Soo; Kim, Jihun; Carlsen, Rebecca; Bowlby, Reanne; Marra, Marco A.; Holt, Robert A.; Jones, Steven J. M.; Ally, Adrian; Brooks, Denise; Tam, Angela; Balasundaram, Miruna; Sipahimalani, Payal; Li, Haiyan I.; Mungall, Karen L.; Moore, Richard A.; Wong, Tina; Bowlby, Reanne; Chuah, Eric; Mayo, Michael; Schein, Jacqueline E.; Ma, Yussanne; Kasaian, Katayoon; Dhalla, Noreen; Mungall, Andrew J.; Robertson, A. Gordon; Thiessen, Nina; Odze, Robert D.; Meyerson, Matthew; Odze, Robert D.; Gehlenborg, Nils; Cibulskis, Kristian; Cherniack, Andrew D.; Lawrence, Michael S.; Kim, Jaegil; Defrietas, Timothy; Noble, Michael S.; Lawrence, Michael; Voet, Doug; Dunford, Andrew; Shih, Juliann; Heiman, David I.; Taylor-Weiner, Amaro; Getz, Gad; Lander, Eric; Chin, Lynda; Cibulskis, Carrie; Murray, Bradley A.; Lin, Pei; Cherniack, Andrew D.; Polak, Paz; Bullman, Susan; Getz, Gad; Frazer, Scott; Pedamallu, Chandra Sekhar; Beroukhim, Rameen; Saksena, Gordon; Stewart, Chip; Gabriel, Stacey B.; Gabriel, Stacey; Meier, Samuel R.; Cho, Juok; Zhang, Hailei; Schumacher, Steven E.; Meyerson, Matthew; Pedamallu, Chandra Sekhar; Beroukhim, Rameen; Bullman, Susan; Shih, Juliann; Cherniack, Andrew D.; Derks, Sarah; Bass, Adam J.; Shih, Juliann; Raphael, Benjamin J.; Wong, Alexandra M.; Wu, Hsin-Ta; Raphael, Benjamin J.; Willis, Joseph E.; Willis, Joseph E.; Bass, Adam J.; Derks, Sarah; McCall, Shannon J.; Cates, Crystal; Garman, Katherine; Sharp, Alexis; Wiznerowicz, Maciej; Wiznerowicz, Maciej; Parfenov, Michael; Ren, Xiaojia; Pantazi, Angeliki; Kucherlapati, Melanie; Kucherlapati, Raju; Hadjipanayis, Angela; Pantazi, Angeliki; Protopopov, Alexei; Pantazi, Angeliki; Ren, Xiaojia; Pantazi, Angeliki; Shmulevich, Ilya; Shmulevich, Ilya; Thorsson, Vésteinn; Reynolds, Sheila M.; Thorsson, Vésteinn; Miller, Michael; Bernard, Brady; Iype, Lisa; Dhankani, Varsha; Sakai, Ryo; Sakai, Ryo; Wang, Kenneth; Sánchez-Vega, Francisco; Gao, Jianjiong; Chakravarty, Debyani; Schultz, Nikolaus; Armenia, Joshua; Kundra, Ritika; Schultz, Nikolaus; Zhang, Hongxin; Schultz, Nikolaus; Arora, Arshi; Shen, Ronglai; Schultz, Nikolaus; Weinhold, Nils; Lehmann, Kjong-Van; Abeshouse, Adam; Sander, Chris; Weinhold, Nils; Kelsen, David; Kelsen, David P.; Janjigian, Yelena; Shaw, Kenna R. Mills; Demchok, John A.; Sheth, Margi; Ferguson, Martin L.; Tarnuzzer, Roy; Yang, Liming; Demchok, John; Zhang, Jiashan; Wang, Zhining; Zenklusen, Jean Claude; Zhang, Julia; Felau, Ina; Zenklusen, Jean Claude; Camargo, M. Constanza; Camargo, M. Constanza; Rabkin, Charles S.; Leraas, Kristen M.; Leraas, Kristen; Wise, Lisa; Lichtenberg, Tara M.; Bowen, Jay; Bowen, Jay; Gerken, Mark; Zmuda, Erik; Frick, Jessica; Ramirez, Nilsa C.; Gastier-Foster, Julie M.; Curtis, Christina; Seoane, Jose A.; Ojesina, Akinyemi I.; Ojesina, Akinyemi I.; Beer, David G.; Ferrer-Torres, Daysha; Gulley, Margaret L.; Luketich, James D.; Luketich, James; Pennathur, Arjun; Pennathur, Arjun; Zhou, Zhongren; Weisenberger, Daniel J.; Weisenberger, Daniel J.; Liu, Wenbin; Akbani, Rehan; Akbani, Rehan; Hegde, Apruva; Liu, Wenbin; Weinstein, John N.; Mills, Gordon B.; Lee, Ju-Seog; Mills, Gordon; Lu, Yiling; Zhang, Wei; Reid, Brian J; Laird, Peter W.; Hinoue, Toshinori; Shen, Hui; Hinoue, Toshinori; Piazuelo, M. Blanca; Schneider, Barbara G.; McLellan, Michael; Appelbaum, Elizabeth L.; Fulton, Lucinda A.; Mardis, Elaine R.; McLellan, Michael D.; Fulton, Robert S.; Schmidt, Heather K.; Wilson, Richard K.; Fronick, Catrina C.; Cordes, Matthew G.; Miller, Christopher A.; Ding, Li; Gehlenborg, Nils; Yang, Lixing; Lee, Semin; Taylor-Weiner, Amaro; Park, Peter J.; Park, Peter J.; Getz, Gad; Getz, Gad; Polak, Paz; Ding, Li; Beroukhim, Rameen; Schumacher, Steven E.; Hadjipanayis, Angela; Kucherlapati, Melanie; Kucherlapati, Raju; Park, Peter J.; Baylin, Stephen B.; Hoadley, Katherine A.; Lai, Phillip H.; Berrios, Mario; Holbrook, Andrea; Bootwalla, Moiz S.; Berg, David J. Van Den; Shaw, Kenna R. 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Kimryn; Dhir, Rajiv; Ajani, Jaffer A.; Ajani, Jaffer A.; Cheong, Jae-Ho; Chudamani, Sudha; Lolla, Laxmi; Liu, Jai; Wu, Ye; Sun, Qiang; Wan, Yunhu; Pihl, Todd; Naresh, Rashi; Sofia, Heidi J.; Hutter, Carolyn M.

doi:10.1038/nature20805

articleNatureJan 1, 2017HYBRID OA

Integrated genomic characterization of oesophageal carcinoma

YS Young Soo ParkJKJihun Kim RC Rebecca CarlsenRB Reanne BowlbyMA Marco A. Marra

University of Ulsan · Pusan National University · +81 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of…

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1,845

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FWCI: 196.22
Percentile: 100%
References: 58

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Authors

334

YS
Young Soo ParkCorresponding
University of Ulsan, Pusan National University
JK
Jihun Kim
Eli and Edythe Broad Foundation, University of Ulsan, Broad Institute
RC
Rebecca Carlsen
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency
RB
Reanne Bowlby
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency
MA
Marco A. Marra
BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre

Topics & keywords

Topics

Keywords

Adenocarcinoma
Cancer research
Esophagus
Pathology
Cancer
Cell of origin
Biology
Carcinoma

UN Sustainable Development Goals

Good health and well-being

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