Pathology of Neurodegenerative Diseases

Neurodegenerative disorders are characterized by progressive loss of selectively vulnerable populations of neurons, which contrasts with select static neuronal loss because of metabolic or toxic disorders. Neurodegenerative diseases can be classified according to primary clinical features (e.g., dementia, parkinsonism, or motor neuron disease), anatomic distribution of neurodegeneration (e.g., frontotemporal degenerations, extrapyramidal disorders, or spinocerebellar degenerations), or principal molecular abnormality. The most common neurodegenerative disorders are amyloidoses, tauopathies, α-synucleinopathies, and TDP-43 proteinopathies. The protein abnormalities in these disorders have abnormal…

• HM
  Henry M. Jackson Foundation
• C
  CurePSP
• D
  Daiichi-Sankyo
• NI
  National Institutes of Health

  Awards: NS084974, AG002132, NS072187, AG037491, AG016574
• DS
  Daiichi Sankyo Europe