Strategies for Fermentation Medium Optimization: An In-Depth Review

Optimization of production medium is required to maximize the metabolite yield. This can be achieved by using a wide range of techniques from classical "one-factor-at-a-time" to modern statistical and mathematical techniques, viz. artificial neural network (ANN), genetic algorithm (GA) etc. Every technique comes with its own advantages and disadvantages, and despite drawbacks some techniques are applied to obtain best results. Use of various optimization techniques in combination also provides the desirable results. In this article an attempt has been made to review the currently used media optimization techniques applied during fermentation process of metabolite production. Comparative analysis of the merits…

• DO
  Department of Science and Technology, Ministry of Science and Technology, India

  Award: SR/FT/LS-190/2009
• CD
  Central Drug Research Institute