Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

Rovira‐Llopis, Susana; Bañuls, Celia; Díaz‐Morales, Noelia; Hernández‐Mijares, Antonio; Rocha, Milagros; Víctor, Víctor M.

doi:10.1016/j.redox.2017.01.013

reviewRedox BiologyJan 16, 2017GOLD OA

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

SRSusana Rovira‐Llopis CBCelia Bañuls NDNoelia Díaz‐Morales AHAntonio Hernández‐Mijares MRMilagros Rocha

Hospital Universitario Doctor Peset · Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · +1 more institution

PubMed

Indexed incrossrefdoajpubmed

Abstract

Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is characterised by mitochondrial dysfunction, high production of reactive oxygen species (ROS) and low levels of ATP. Mitochondrial fusion is modulated by different proteins, including mitofusin-1 (MFN1), mitofusin-2 (MFN2) and optic atrophy (OPA-1), while fission is controlled by mitochondrial fission 1 (FIS1), dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF). PARKIN and (PTEN)-induced putative kinase 1 (PINK1) participate in the process…

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648

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FWCI: 15.03
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Topics & keywords

Topics

Keywords

MFN2
FIS1
Mitochondrial fission
Mitophagy
mitochondrial fusion
MFN1
PINK1
DNM1L

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