Keeping It All Going—Complement Meets Metabolism

The complement system is an evolutionary old and crucial component of innate immunity key to the detection and removal of invading pathogens. It was initially discovered as a liver-derived sentinel system circulating in serum, the lymph and interstitial fluids that mediates the opsonization and lytic killing of bacteria, fungi and viruses and the initiation of the general inflammatory responses. Although work performed specifically in the last five decades identified complement also as a critical instructor of adaptive immunity – indicating that complement’s function is likely broader than initially anticipated - the dominant opinion among researchers and clinicians was that the key complement functions were…

• W
  Wellcome

  Award: 102932/Z/13/Z
• WT
  Wellcome Trust
• NI
  National Institute for Health and Care Research

  Award: J006742/1
• KC
  King's College London

  Award: MR/J006742/1
• NI
  National Institutes of Health

  Award: M9999
• MR
  Medical Research Council

  Awards: J006742/1, MR/J006742/1, MR/J006742/1
• NH
  National Heart, Lung, and Blood Institute
• ND
  NHLBI Division of Intramural Research