Beyond the Hofmeister Series: Ion-Specific Effects on Proteins and Their Biological Functions

Ions differ in their ability to salt out proteins from solution as expressed in the lyotropic or Hofmeister series of cations and anions. Since its first formulation in 1888, this series has been invoked in a plethora of effects, going beyond the original salting out/salting in idea to include enzyme activities and the crystallization of proteins, as well as to processes not involving proteins like ion exchange, the surface tension of electrolytes, or bubble coalescence. Although it has been clear that the Hofmeister series is intimately connected to ion hydration in homogeneous and heterogeneous environments and to ion pairing, its molecular origin has not been fully understood. This situation could have been…

• DF
  Deutsche Forschungsgemeinschaft
• GA
  Grantová Agentura České Republiky

  Awards: 16-57654Y, 16-01074S
• DO
  Division of Chemistry

  Award: CHE-1413307