Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease
Georgetown University · Georgetown University Medical Center · +6 more institutions
Abstract
Treatment of mild-moderate Alzheimer's disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and activities of daily living (ADL) scores.
For this retrospective study, we examined banked CSF and plasma samples from a subset of AD subjects with CSF Aβ42
Citation impact
- FWCI
- 30.32
- Percentile
- 100%
- References
- 53
Authors
7- CMCharbel MoussaCorresponding
Georgetown University, Georgetown University Medical Center, Foundation Center, Biomedical Research Foundation, Parkinson's Foundation
- MHMichaeline Hebron
Georgetown University, Georgetown University Medical Center, Foundation Center, Parkinson's Foundation
- XHXu Huang
Georgetown University, Georgetown University Medical Center, Foundation Center, Parkinson's Foundation
- JAJaeil Ahn
Georgetown University
- RARobert A. Rissman
Georgetown University, Georgetown University Medical Center
Topics & keywords
- Resveratrol
- Medicine
- Inflammation
- Placebo
- Internal medicine
- Biomarker
- Neurology
- Alzheimer's disease
- Good health and well-being