reviewCold Spring Harbor Perspectives in BiologyJan 20, 2017BRONZE OA

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

SSShomyseh SanjabiSOSoyoung OhMOMing O. Li

University of California, San Francisco · Gladstone Institutes · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Transforming growth factor β (TGF-β) is a pleiotropic cytokine involved in both suppressive and inflammatory immune responses. After 30 years of intense study, we have only begun to elucidate how TGF-β alters immunity under various conditions. Under steady-state conditions, TGF-β regulates thymic T-cell selection and maintains homeostasis of the naïve T-cell pool. TGF-β inhibits cytotoxic T lymphocyte (CTL), Th1-, and Th2-cell differentiation while promoting peripheral (p)Treg-, Th17-, Th9-, and Tfh-cell generation, and T-cell tissue residence in response to immune challenges. Similarly, TGF-β controls the proliferation, survival, activation, and differentiation of B cells, as well as the development and…

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606
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Authors

3

Topics & keywords

Topics
Keywords
  • Biology
  • Immune system
  • Immunology
  • Cytotoxic T cell
  • Transforming growth factor
  • Cell biology
  • Autoimmunity
  • Cytokine
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