Integrated genomic and molecular characterization of cervical cancer

Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered amplifications in immune targets CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2), and the BCAR4 long non-coding RNA, which has been associated with response to lapatinib. Integration of human papilloma virus (HPV) was observed in all HPV18-related samples and 76% of…

• SI
  SRA International
• MG
  Massachusetts General Hospital
• MI
  Massachusetts Institute of Technology
• MS
  Memorial Sloan-Kettering Cancer Center
• HU
  Harvard University
• NC
  Nationwide Children's Hospital
• JH
  Johns Hopkins University
• BR
  Beckman Research Institute, City of Hope
• UO
  University of South Carolina
• LH
  London Health Sciences Centre
• CM
  Cedars-Sinai Medical Center
• BI
  Broad Institute
• CM
  Canada's Michael Smith Genome Sciences Centre
• BI
  Buck Institute for Research on Aging
• L
  Leidos
• HD
  Hospital de Câncer de Barretos
• UI
  Universitetet i Bergen
• NI
  National Institutes of Health

  Award: 10,11
• UO
  University of Texas MD Anderson Cancer Center
• SO
  School of Medicine, Indiana University
• RI
  Research Institute, Nationwide Children's Hospital
• SK
  Sidney Kimmel Comprehensive Cancer Center
• NC
  National Cancer Institute