Nanoparticles Coated with Neutrophil Membranes Can Effectively Treat Cancer Metastasis

The dissemination, seeding, and colonization of circulating tumor cells (CTCs) serve as the root of distant metastasis. As a key step in the early stage of metastasis formation, colonization of CTCs in the (pre-)metastatic niche appears to be a valuable target. Evidence showed that inflammatory neutrophils possess both a CTC- and niche-targeting property by the intrinsic cell adhesion molecules on neutrophils. Inspired by this mechanism, we developed a nanosize neutrophil-mimicking drug delivery system (NM-NP) by coating neutrophils membranes on the surface of poly(latic-co-glycolic acid) nanoparticles (NPs). The membrane-associated protein cocktails on neutrophils membrane were mostly translocated to the…

• NN
  National Natural Science Foundation of China

  Awards: 81673019, 61227017, 81573382, 61425006
• MO
  Ministry of Science and Technology of the People's Republic of China

  Awards: 2011CB910404, 2012CB966801
• SE
  Shanghai Education Development Foundation

  Award: 15SG14
• SM
  Shanghai Municipal Education Commission

  Award: 15SG14
• SA
  Science and Technology Commission of Shanghai Municipality

  Award: 15540723700