Caloric restriction improves health and survival of rhesus monkeys
National Institute on Aging · University of Wisconsin–Madison · +7 more institutions
Abstract
Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact in nonhuman primates has been controversial. In the late 1980s two parallel studies were initiated to determine the effect of CR in rhesus monkeys. The University of Wisconsin study reported a significant positive impact of CR on survival, but the National Institute on Aging study detected no significant survival effect. Here we present a direct comparison of longitudinal data from both studies including survival, bodyweight, food intake, fasting glucose levels and age-related morbidity. We describe differences in study design that could contribute to differences in…
Citation impact
- FWCI
- 37.97
- Percentile
- 100%
- References
- 52
Authors
10- JAJulie A. MattisonCorresponding
National Institute on Aging
- RJRicki J. Colman
University of Wisconsin–Madison
- TMT. Mark Beasley
University of Alabama at Birmingham, Geriatric Research Education and Clinical Center, Birmingham VA Medical Center
- DBDavid B. Allison
University of Alabama at Birmingham
- JWJoseph W. Kemnitz
University of Wisconsin System, University of Wisconsin–Madison
Topics & keywords
- Caloric theory
- Malnutrition
- Caloric intake
- Medicine
- Longitudinal study
- Physiology
- Gerontology
- Biology
- Zero hunger
Funding
- UOUniversity of Wisconsin-MadisonAward: P51OD011106
- NINational Institutes of HealthAwards: P51RR000167, P51RR000167/P51OD011106, R01AG040178, P01AG011915, R01AG037000, P51OD011106
- NINational Institute on AgingAwards: P51RR000167, P51OD011106
- NCNational Center for Research ResourcesAwards: P51RR000167/P51OD011106, P51RR000167, P51OD011106
- OOOffice of Research Infrastructure Programs, National Institutes of HealthAward: P51OD011106