Insights into Cystic Fibrosis Polymicrobial Consortia: The Role of Species Interactions in Biofilm Development, Phenotype, and Response to In-Use Antibiotics

Cystic Fibrosis (CF) airways disease involves complex polymicrobial infections where different bacterial species can interact and influence each other and/or even interfere with the whole community. To gain insights into the role that interactions between Pseudomonas aeruginosa in co-culture with Staphylococcus aureus, Inquilinus limosus and Stenotrophomonas maltophilia may play in infection, the reciprocal effect during biofilm formation and the response of dual biofilms towards ciprofloxacin under in vitro atmospheres with different oxygen availabilities were evaluated. Biofilm formation kinetics showed that the growth of S. aureus, I. limosus and S. maltophilia was disturbed in the presence of P.…

• UD
  Universidade do Minho
• FP
  Fundação para a Ciência e a Tecnologia

  Awards: 01-0145, COMPETE, POCI-01-0145, FCOMP-01-0124-FEDER-027462, SFRH/BPD/95616/2013, UMINHO/BD/25/2016, NORTE-07-0124-FEDER-000025, COMPETE 2020, RECI/BBB-EBI/0179/2012, POCI-01-, UID/BIO/04469, POCI-01-0145-FEDER-006684, UID/BIO/04469/2013, POCI-01-0145-FEDER, FCOMP-01-0124-FEDER