Biological Photothermal Nanodots Based on Self-Assembly of Peptide–Porphyrin Conjugates for Antitumor Therapy
Institute of Process Engineering · University of Chinese Academy of Sciences
Abstract
Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote-controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy to fabricate photothermal nanodots through peptide-modulated self-assembly of photoactive porphyrins. The self-assembling nature of porphyrins induces the formation of J-aggregates as substructures of the nanodots, and thus enables the fabrication of nanodots with totally inhibited fluorescence emission and singlet oxygen production, leading to a high light-to-heat conversion efficiency of the nanodots. The peptide…
Citation impact
- FWCI
- 56.54
- Percentile
- 100%
- References
- 49
Authors
6- QZQianli ZouCorresponding
Institute of Process Engineering
- MAManzar Abbas
Institute of Process Engineering, University of Chinese Academy of Sciences
- LZLuyang Zhao
Institute of Process Engineering
- SLShukun Li
Institute of Process Engineering, University of Chinese Academy of Sciences
- GSGuizhi Shen
Institute of Process Engineering
Topics & keywords
- Nanodot
- Photothermal therapy
- Porphyrin
- Chemistry
- Nanotechnology
- Photothermal effect
- Photodynamic therapy
- Materials science