Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms
Brigham and Women's Hospital · Harvard University
Abstract
Practitioners of ancient societies from the time of Hippocrates and earlier recognized and treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or inhibit proinflammatory chemical mediators. More selective drugs are available today, but this therapeutic concept has not changed. Because the acute inflammatory response is host protective to contain foreign invaders, much of today's pharmacopeia can cause serious unwanted side effects, such as immune suppression. Uncontrolled inflammation is now considered path‐ophysiologic and is associated with many widely occurring diseases such as cardiovascular disease, neurodegen‐erative diseases, diabetes, obesity, and asthma, as well…
Citation impact
- FWCI
- 42.35
- Percentile
- 100%
- References
- 171
Authors
1Topics & keywords
- Inflammation
- Resolution (logic)
- Decoding methods
- Neuroscience
- Medicine
- Immunology
- Computational biology
- Biology
- Good health and well-being