reviewActa BiomaterialiaJan 22, 2017HYBRID OA

Promoting tissue regeneration by modulating the immune system

Monash University · Australian Regenerative Medicine Institute · +1 more institution

PubMed
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Abstract

The immune system plays a central role in tissue repair and regeneration. Indeed, the immune response to tissue injury is crucial in determining the speed and the outcome of the healing process, including the extent of scarring and the restoration of organ function. Therefore, controlling immune components via biomaterials and drug delivery systems is becoming an attractive approach in regenerative medicine, since therapies based on stem cells and growth factors have not yet proven to be broadly effective in the clinic. To integrate the immune system into regenerative strategies, one of the first challenges is to understand the precise functions of the different immune components during the tissue healing…

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