Circular RNAs in human cancer
Central South University · Third Xiangya Hospital · +4 more institutions
Abstract
CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique structure, they are more stable than linear RNAs. CircRNAs play important roles in the carcinogenesis of cancer. The expression of circRNAs is correlated with patients' clinical characteristics, and circRNAs play a vital role in many aspects of malignant phenotypes, including cell cycle, apoptosis, vascularization, and invasion; metastasis as a RNA sponge, binding to RBP; or translation. Therefore, it is meaningful to further study the mechanism of interactions between circRNAs and tumors. The role of…
Citation impact
- FWCI
- 25.68
- Percentile
- 100%
- References
- 62
Authors
17- YWYumin WangCorresponding
Central South University, Third Xiangya Hospital, Xiangya Hospital Central South University
- YMYongzhen Mo
Xiangya Hospital Central South University, Central South University, Third Xiangya Hospital
- ZGZhaojian Gong
Central South University, Second Xiangya Hospital of Central South University
- XYXiang Yang
Central South University, Xiangya Hospital Central South University
- MYMo Yang
Central South University, Xiangya Hospital Central South University
Topics & keywords
- Biology
- Circular RNA
- Carcinogenesis
- Computational biology
- Mechanism (biology)
- microRNA
- Translation (biology)
- Cancer
- Good health and well-being