A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)

Jacka, Felice N.; O’Neil, Adrienne; Opie, Rachelle; Itsiopoulos, Catherine; Cotton, Sue; Mohebbi, Mohammedreza; Castle, David; Dash, Sarah; Mihalopoulos, Cathrine; Chatterton, Mary Lou; Brazionis, Laima; Dean, Olivia; Hodge, Allison; Berk, Michael

doi:10.1186/s12916-017-0791-y

articleBMC MedicineJan 28, 2017GOLD OA

A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)

FNFelice N. Jacka AOAdrienne O’Neil RORachelle Opie CICatherine Itsiopoulos SCSue Cotton

Deakin University · University of Melbourne · +5 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

The possible therapeutic impact of dietary changes on existing mental illness is largely unknown. Using a randomised controlled trial design, we aimed to investigate the efficacy of a dietary improvement program for the treatment of major depressive episodes. ‘SMILES’ was a 12-week, parallel-group, single blind, randomised controlled trial of an adjunctive dietary intervention in the treatment of moderate to severe depression. The intervention consisted of seven individual nutritional consulting sessions delivered by a clinical dietician. The control condition comprised a social support protocol to the same visit schedule and length. Depression symptomatology was the primary endpoint, assessed using the…

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Topics

Keywords

Medicine
Depression (economics)
Randomized controlled trial
Clinical trial
Physical therapy
Internal medicine

UN Sustainable Development Goals

Zero hunger

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