Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species
Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · +7 more institutions
Abstract
Reactive oxygen species (ROS) plays a key role in therapeutic effects as well as side effects of platinum drugs. Cisplatin mediates activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX), which triggers oxygen (O2) to superoxide radical (O2•–) and its downstream H2O2. Through the Fenton’s reaction, H2O2 could be catalyzed by Fe2+/Fe3+ to the toxic hydroxyl radicals (•OH), which cause oxidative damages to lipids, proteins, and DNA. By taking the full advantage of Fenton’s chemistry, we herein demonstrated tumor site-specific conversion of ROS generation induced by released cisplatin and Fe2+/Fe3+ from iron-oxide nanocarriers with cisplatin(IV) prodrugs for enhanced anticancer activity…
Citation impact
- FWCI
- 29.81
- Percentile
- 100%
- References
- 58
Authors
11- PMPing’an MaCorresponding
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- HXHaihua Xiao
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, State Key Laboratory of Polymer Physics and Chemistry
- YCYu Chang
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences
- JLJianhua Liu
Jilin University, Second Affiliated Hospital of Jilin University, State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
- ZCZiyong Cheng
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
Topics & keywords
- Nanocarriers
- Reactive oxygen species
- Cisplatin
- Chemistry
- Oxygen
- Chemotherapy
- Nanotechnology
- Nanoparticle