Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli
Radboud University Nijmegen · The University of Western Australia · +4 more institutions
Abstract
On the 400th anniversary of Harvey's Lumleian lectures, this review focuses on "hemodynamic" forces associated with the movement of blood through arteries in humans and the functional and structural adaptations that result from repeated episodic exposure to such stimuli. The late 20th century discovery that endothelial cells modify arterial tone via paracrine transduction provoked studies exploring the direct mechanical effects of blood flow and pressure on vascular function and adaptation in vivo. In this review, we address the impact of distinct hemodynamic signals that occur in response to exercise, the interrelationships between these signals, the nature of the adaptive responses that manifest under…
Citation impact
- FWCI
- 38.65
- Percentile
- 100%
- References
- 332
Authors
5- DJDaniel J. GreenCorresponding
Radboud University Nijmegen, The University of Western Australia, University of Missouri Health System, Radboud University Medical Center, Liverpool John Moores University, University of Missouri
- MTMaria T. E. Hopman
Radboud University Nijmegen, The University of Western Australia, University of Missouri Health System, Radboud University Medical Center, Liverpool John Moores University, University of Missouri
- JPJaume Padilla
Radboud University Nijmegen, The University of Western Australia, University of Missouri Health System, Radboud University Medical Center, Liverpool John Moores University, University of Missouri
- MHM. Harold Laughlin
Radboud University Nijmegen, The University of Western Australia, University of Missouri Health System, Radboud University Medical Center, Liverpool John Moores University, University of Missouri
- DHDick H. J. Thijssen
Radboud University Nijmegen, The University of Western Australia, University of Missouri Health System, Radboud University Medical Center, Liverpool John Moores University, University of Missouri
Topics & keywords
- Hemodynamics
- Blood pressure
- Blood flow
- Medicine
- Artery
- Internal medicine
- Cardiology
- Neuroscience
- Good health and well-being