CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer

Griffith, Malachi; Spies, Nicholas C.; Krysiak, Kilannin; McMichael, Joshua F.; Coffman, Adam; Danos, Arpad; Ainscough, Benjamin J.; Ramirez, Cody A.; Rieke, Damian; Kujan, Lynzey; Barnell, Erica K.; Wagner, Alex H.; Skidmore, Zachary L.; Wollam, Amber Z.; Liu, Connor J.; Jones, Martin; Bilski, Rachel L; Lesurf, Robert; Feng, Yan-Yang; Shah, Nakul M.; Bonakdar, Melika; Trani, Lee; Matlock, Matthew K.; Ramu, Avinash; Campbell, Katie M.; Spies, Gregory C.; Graubert, Aaron; Gangavarapu, Karthik; Eldred, James M.; Larson, David E.; Walker, Jason; Good, Benjamin M.; Wu, Chunlei; Su, Andrew I.; Dienstmann, Rodrigo; Margolin, Adam A.; Tamborero, David; López-Bigas, Núria; Jones, Steven J.M.; Bose, Ron; Spencer, David H.; Wartman, Lukas D.; Wilson, Richard K.; Mardis, Elaine R.; Griffith, Obi L.

doi:10.1038/ng.3774

articleNature GeneticsJan 31, 2017HYBRID OA

CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer

MGMalachi Griffith NCNicholas C. Spies KKKilannin Krysiak JFJoshua F. McMichael ACAdam Coffman

James S. McDonnell Foundation · Washington University in St. Louis · +7 more institutions

PubMed

Indexed incrossrefdatacitepubmed

Abstract

CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types. CIViC is committed to open-source code, open-access content, public application programming interfaces (APIs) and provenance of supporting evidence to allow for the transparent creation of current and accurate variant interpretations for use in cancer precision medicine.

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Topics & keywords

Topics

Keywords

Crowdsourcing
Relevance (law)
Interpretation (philosophy)
Biology
Precision medicine
Open source
Annotation
Computational biology

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