Mesenchymal stem cells: key players in cancer progression
Prostate Cancer Research · Clinical Science Institute
Abstract
Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, cells of the immune system and mesenchymal stem cells (MSCs). MSCs are multipotent stromal cells that are known to reside in various areas such as the bone marrow, fat and dental pulp. MSCs have been found to migrate towards inflammatory sites and studies have shown that they also migrate towards and incorporate into the tumour. The key question is how they interact there. MSCs may interact with tumour cells through paracrine signalling. On the other hand, MSCs have the capacity to…
Citation impact
- FWCI
- 31.15
- Percentile
- 100%
- References
- 119
Authors
3Topics & keywords
- Mesenchymal stem cell
- Biology
- Paracrine signalling
- Cancer research
- Stromal cell
- Tumor microenvironment
- Metastasis
- Clinical uses of mesenchymal stem cells
- Good health and well-being