Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization
Ospedale Policlinico San Martino · National Cancer Research Institute · +6 more institutions
Abstract
Abstract Mesenchymal Stem Cells (MSCs) are effective therapeutic agents enhancing the repair of injured tissues mostly through their paracrine activity. Increasing evidences show that besides the secretion of soluble molecules, the release of extracellular vesicles (EVs) represents an alternative mechanism adopted by MSCs. Since macrophages are essential contributors toward the resolution of inflammation, which has emerged as a finely orchestrated process, the aim of the present study was to carry out a detailed characterization of EVs released by human adipose derived-MSCs to investigate their involvement as modulators of MSC anti-inflammatory effects inducing macrophage polarization. The EV-isolation method…
Citation impact
- FWCI
- 19.06
- Percentile
- 100%
- References
- 54
Authors
13- CLClaudia Lo Sicco
Ospedale Policlinico San Martino, National Cancer Research Institute, University of Genoa
- DRDaniele Reverberi
Ospedale Policlinico San Martino, National Cancer Research Institute
- CBCarolina Balbi
University of Genoa
- VUValentina Ulivi
University of Genoa
- EPElisa Principi
University of Genoa
Topics & keywords
- Mesenchymal stem cell
- Paracrine signalling
- Cell biology
- Downregulation and upregulation
- Inflammation
- MyoD
- Extracellular vesicle
- Macrophage
- Good health and well-being