Gold nanoparticle‐mediated photothermal therapy: applications and opportunities for multimodal cancer treatment
University of Delaware · Helen Dowling Instituut
Abstract
Photothermal therapy (PTT), in which nanoparticles embedded within tumors generate heat in response to exogenously applied laser light, has been well documented as an independent strategy for highly selective cancer treatment. Gold-based nanoparticles are the main mediators of PTT because they offer: (1) biocompatibility, (2) small diameters that enable tumor penetration upon systemic delivery, (3) simple gold-thiol bioconjugation chemistry for the attachment of desired molecules, (4) efficient light-to-heat conversion, and (5) the ability to be tuned to absorb near-infrared light, which penetrates tissue more deeply than other wavelengths of light. In addition to acting as a standalone therapy, gold…
Citation impact
- FWCI
- 35.03
- Percentile
- 100%
- References
- 110
Authors
2Topics & keywords
- Photothermal therapy
- Colloidal gold
- Nanotechnology
- Cancer treatment
- Photothermal effect
- Cancer therapy
- Drug delivery
- Materials science
- Good health and well-being