Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin
Chonnam National University · Gwangju National University of Education · +7 more institutions
Abstract
Resulted in phenotypic and functional activation of intratumoral macrophages with M1 phenotypes and a reciprocal reduction in M2-like suppressive activities. Together, these findings provide evidence that nonvirulent tumor-targeting bacteria releasing multiple TLR ligands can be used as cancer immunotherapeutics.
Citation impact
- FWCI
- 32.87
- Percentile
- 100%
- References
- 54
Authors
14- JZJin Zheng
Chonnam National University, Gwangju National University of Education, Chonnam National University Hwasun Hospital
- VHVu H. Nguyen
City of Hope, Chonnam National University Hwasun Hospital, Beckman Research Institute
- SJShengnan Jiang
Chonnam National University, Central South University, Hainan Medical University
- SPSeung‐Hwan Park
Korea Research Institute of Bioscience and Biotechnology
- WTWenzhi Tan
Chonnam National University, Chonnam National University Hospital
Topics & keywords
- Flagellin
- Heterologous
- Salmonella
- Microbiology
- Cancer immunotherapy
- Genetically engineered
- Immunotherapy
- Immune system
- Good health and well-being