Pathophysiology of Migraine: A Disorder of Sensory Processing
University of Bern · Universität Hamburg · +4 more institutions
Abstract
Plaguing humans for more than two millennia, manifest on every continent studied, and with more than one billion patients having an attack in any year, migraine stands as the sixth most common cause of disability on the planet. The pathophysiology of migraine has emerged from a historical consideration of the “humors” through mid-20th century distraction of the now defunct Vascular Theory to a clear place as a neurological disorder. It could be said there are three questions: why, how, and when? Why: migraine is largely accepted to be an inherited tendency for the brain to lose control of its inputs. How: the now classical trigeminal durovascular afferent pathway has been explored in laboratory and clinic;…
Citation impact
- FWCI
- 94.11
- Percentile
- 100%
- References
- 901
Authors
6- PJPeter J. GoadsbyCorresponding
University of Bern, Universität Hamburg, University of California, San Francisco, King's College London, Neurosciences Institute, University Hospital of Bern
- PRPhilip R. Holland
University of Bern, Universität Hamburg, University of California, San Francisco, King's College London, Neurosciences Institute, University Hospital of Bern
- MMMargarida Martins-Oliveira
University of Bern, Universität Hamburg, University of California, San Francisco, King's College London, Neurosciences Institute, University Hospital of Bern
- JHJan Hoffmann
University of Bern, Universität Hamburg, University of California, San Francisco, King's College London, Neurosciences Institute, University Hospital of Bern
- CJChristoph J. Schankin
University of Bern, Universität Hamburg, University of California, San Francisco, King's College London, Neurosciences Institute, University Hospital of Bern
Topics & keywords
- Migraine
- Neuroscience
- Phonophobia
- Triptans
- Calcitonin gene-related peptide
- Medicine
- Cortical spreading depression
- Photophobia