Anthracycline Chemotherapy and Cardiotoxicity

Anthracycline chemotherapy maintains a prominent role in treating many forms of cancer. Cardiotoxic side effects limit their dosing and improved cancer outcomes expose the cancer survivor to increased cardiovascular morbidity and mortality. The basic mechanisms of cardiotoxicity may involve direct pathways for reactive oxygen species generation and topoisomerase 2 as well as other indirect pathways. Cardioprotective treatments are few and those that have been examined include renin angiotensin system blockade, beta blockers, or the iron chelator dexrazoxane. New treatments exploiting the ErbB or other novel pro-survival pathways, such as conditioning, are on the cardioprotection horizon. Even in the…

• NI
  National Institute for Health and Care Research

  Award: BRC233/CM/SD/101320
• UC
  University College London
• UC
  University College London Hospitals NHS Foundation Trust
• UB
  UCLH Biomedical Research Centre

  Award: BRC 273/CM/CR/101320