The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment
Imperial College London · King's College London · +5 more institutions
Abstract
Bipolar affective disorder is a common neuropsychiatric disorder. Although its neurobiological underpinnings are incompletely understood, the dopamine hypothesis has been a key theory of the pathophysiology of both manic and depressive phases of the illness for over four decades. The increased use of antidopaminergics in the treatment of this disorder and new in vivo neuroimaging and post-mortem studies makes it timely to review this theory. To do this, we conducted a systematic search for post-mortem, pharmacological, functional magnetic resonance and molecular imaging studies of dopamine function in bipolar disorder. Converging findings from pharmacological and imaging studies support the hypothesis that a…
Citation impact
- FWCI
- 26.86
- Percentile
- 100%
- References
- 158
Authors
7- AHAbhishekh H. AshokCorresponding
Imperial College London, King's College London, South London and Maudsley NHS Foundation Trust, Hammersmith Hospital, MRC London Institute of Medical Sciences
- TRTiago Reis Marques
Hammersmith Hospital, MRC London Institute of Medical Sciences, King's College London, South London and Maudsley NHS Foundation Trust, Imperial College London
- SJSameer Jauhar
Imperial College London, King's College London, South London and Maudsley NHS Foundation Trust, Hammersmith Hospital, MRC London Institute of Medical Sciences
- MMMatthew M. Nour
Imperial College London, King's College London, MRC London Institute of Medical Sciences, Hammersmith Hospital
- GMG M Goodwin
University of Oxford, Warneford Hospital
Topics & keywords
- Dopaminergic
- Dopamine
- Dopamine transporter
- Mania
- Bipolar disorder
- Neuroscience
- Psychology
- Dopamine receptor D2
- Good health and well-being