Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

Hill‐Burns, Erin M.; Debelius, Justine W.; Morton, James T.; Wissemann, William T.; Lewis, Matthew R.; Wallen, Zachary D.; Peddada, Shyamal D.; Factor, Stewart A.; Molho, Eric; Zabetian, Cyrus P.; Knight, Rob; Payami, Haydeh

doi:10.1002/mds.26942

articleMovement DisordersFeb 14, 2017Closed access

Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

EMErin M. Hill‐Burns JWJustine W. Debelius JTJames T. Morton WTWilliam T. Wissemann MRMatthew R. Lewis

University of Alabama at Birmingham · University of California San Diego · +6 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Background

There is mounting evidence for a connection between the gut and Parkinson's disease (PD). Dysbiosis of gut microbiota could explain several features of PD.

Objective

The objective of this study was to determine if PD involves dysbiosis of gut microbiome, disentangle effects of confounders, and identify candidate taxa and functional pathways to guide research.

Citation impact

875

total citations

FWCI: 28.14
Percentile: 100%
References: 58

Citations per year

Authors

12

Topics & keywords

Topics

Keywords

Parkinson's disease
Disease
Microbiome
Gut microbiome
Medicine
Neuroscience
Psychology
Biology

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Funding

NI
National Institute of Neurological Disorders and Stroke
Award: R01036960