Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Large-Scale Epidemiology: A Primer on -Omic Technologies

Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel biomarkers for cardiometabolic diseases and clarified the molecular associations of established risk factors. A quantitative metabolomics platform based on nuclear magnetic resonance spectroscopy has found widespread use, already profiling over 400,000 blood samples. Over 200 metabolic measures are quantified per sample; in addition to many biomarkers routinely used in epidemiology, the method simultaneously provides fine-grained lipoprotein subclass profiling and quantification of circulating fatty acids, amino acids, gluconeogenesis-related metabolites, and many other molecules from multiple metabolic pathways. Here we…

• W
  Wellcome
• IY
  Itä-Suomen Yliopisto
• WT
  Wellcome Trust
• BH
  British Heart Foundation
• UO
  University of Bristol

  Awards: MC_UU_12013/1, MC_UU_12013/5
• AO
  Academy of Finland
• T
  Tekes
• NN
  Novo Nordisk
• OY
  Oulun Yliopisto
• PN
  Paavo Nurmen Säätiö
• D
  Diabetestutkimussäätiö
• MR
  Medical Research Council

  Awards: MC_UU_12013, MC_UU_12013/5, MC_UU_12013/1
• BU
  Biocenter, University of Oulu