PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

The discovery of poly(ADP-ribose) >50 years ago opened a new field, leading the way for the discovery of the poly(ADP-ribose) polymerase (PARP) family of enzymes and the ADP-ribosylation reactions that they catalyze. Although the field was initially focused primarily on the biochemistry and molecular biology of PARP-1 in DNA damage detection and repair, the mechanistic and functional understanding of the role of PARPs in different biological processes has grown considerably of late. This has been accompanied by a shift of focus from enzymology to a search for substrates as well as the first attempts to determine the functional consequences of site-specific ADP-ribosylation on those substrates. Supporting these…

• CP
  Cancer Prevention and Research Institute of Texas

  Award: RP160319
• NI
  National Institutes of Health

  Award: R01 DK069710
• CH
  Cecil H. and Ida Green Center for Reproductive Biology Sciences

  Award: R01 DK069710
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Awards: DK069710, R01 DK069710