Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design
Bioinformatics Institute · Duke-NUS Medical School · +4 more institutions
Abstract
Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great potential for combating bacterial resistance. AMPs can be both bacteriostatic and bactericidal, induce rapid killing and display a lower propensity to develop resistance than do conventional antibiotics. Despite significant progress in the past 30 years, no peptide antibiotic has reached the clinic yet. Poor understanding of the action mechanisms and lack of rational design principles have been the two major obstacles that have slowed progress. Technological developments are now enabling multidisciplinary approaches including molecular dynamics simulations combined with biophysics and microbiology toward providing valuable…
Citation impact
- FWCI
- 28.49
- Percentile
- 100%
- References
- 203
Authors
6- JLJianguo Li
Bioinformatics Institute, Duke-NUS Medical School, Singapore Eye Research Institute, Agency for Science, Technology and Research
- JKJun-Jie Koh
Singapore Eye Research Institute
- SLShouping Liu
Singapore Eye Research Institute
- RLRajamani Lakshminarayanan
Singapore Eye Research Institute
- CVChandra Verma
Bioinformatics Institute, Agency for Science, Technology and Research, Singapore Eye Research Institute, Nanyang Technological University, National University of Singapore
Topics & keywords
- Antimicrobial peptides
- Antimicrobial
- Chemistry
- Biochemical engineering
- Computational biology
- Computer science
- Biology
- Engineering