Ultraflexible nanoelectronic probes form reliable, glial scar–free neural integration

Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility, and cellular surgical footprints form reliable, glial scar-free neural integration. We demonstrated that NET electrodes reliably detected and tracked individual units for months; their impedance, noise level, single-unit recording yield, and the signal amplitude remained stable during long-term implantation. In vivo two-photon imaging and postmortem histological analysis revealed seamless,…

• NI
  National Institute of Neurological Disorders and Stroke

  Awards: ID0EVXBK15131, R01NS082518, R01EB011556, ID0EOTBK15130