Dynamics of the human gut microbiome in inflammatory bowel disease

Inflammatory bowel disease (IBD) is characterized by flares of inflammation with a periodic need for increased medication and sometimes even surgery. The aetiology of IBD is partly attributed to a deregulated immune response to gut microbiome dysbiosis. Cross-sectional studies have revealed microbial signatures for different IBD subtypes, including ulcerative colitis, colonic Crohn's disease and ileal Crohn's disease. Although IBD is dynamic, microbiome studies have primarily focused on single time points or a few individuals. Here, we dissect the long-term dynamic behaviour of the gut microbiome in IBD and differentiate this from normal variation. Microbiomes of IBD subjects fluctuate more than those of…

• NS
  National Science Foundation
• HH
  Howard Hughes Medical Institute
• HR
  Hospital Research Foundation
• UÖ
  Universitetssjukhuset Örebro
• NI
  National Institutes of Health
• DO
  Division of Undergraduate Education
• PN
  Pacific Northwest National Laboratory

  Award: DE-AC05-76RLO1830